PCI Neuroscience

219

Title *

Multisensory coding of angular head velocity in the retrosplenial cortexuse asterix (*) to get italics

Authors *

Sepiedeh Keshavarzi, Edward F. Bracey, Richard A. Faville, Dario Campagner, Adam L. Tyson, Stephen C. Lenzi, Tiago Branco, Troy W. MargriePlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2022

Picture *

Abstract *

<p>To successfully navigate the environment, animals depend on their ability to continuously track their heading direction and speed. Neurons that encode angular head velocity (AHV) are fundamental to this process, yet the contribution of various motion signals to AHV coding in the cortex remains elusive. By performing chronic single-unit recordings in the retrosplenial cortex (RSP) of the mouse and tracking the activity of individual AHV cells between freely moving and head-restrained conditions, we find that vestibular inputs dominate AHV signaling. Moreover, the addition of visual inputs onto these neurons increases the gain and signal-to-noise ratio of their tuning during active exploration. Psychophysical experiments and neural decoding further reveal that vestibular-visual integration increases the perceptual accuracy of angular self-motion and the fidelity of its representation by RSP ensembles. We conclude that while cortical AHV coding requires vestibular input, where possible, it also uses vision to optimize heading estimation during navigation.</p>

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Keywords (optional)

retrosplenial cortex, self-motion, navigation, vestibular, optic-flow, Neuropixels, head motion, head velocity, head direction

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Behavioral/Cognitive Neuroscience, Electrophysiology, Neuronal assembly, Rodent model system, Systems/Circuit Neuroscience

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Submission date

2024-08-29 15:59:23

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Balázs Hangya

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