PCI Neuroscience

219

Title *

Multisensory coding of angular head velocity in the retrosplenial cortexuse asterix (*) to get italics

Authors *

Sepiedeh Keshavarzi, Edward F. Bracey, Richard A. Faville, Dario Campagner, Adam L. Tyson, Stephen C. Lenzi, Tiago Branco, Troy W. MargriePlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2022

Picture *

Abstract *

<p>To successfully navigate the environment, animals depend on their ability to continuously track their heading direction and speed. Neurons that encode angular head velocity (AHV) are fundamental to this process, yet the contribution of various motion signals to AHV coding in the cortex remains elusive. By performing chronic single-unit recordings in the retrosplenial cortex (RSP) of the mouse and tracking the activity of individual AHV cells between freely moving and head-restrained conditions, we find that vestibular inputs dominate AHV signaling. Moreover, the addition of visual inputs onto these neurons increases the gain and signal-to-noise ratio of their tuning during active exploration. Psychophysical experiments and neural decoding further reveal that vestibular-visual integration increases the perceptual accuracy of angular self-motion and the fidelity of its representation by RSP ensembles. We conclude that while cortical AHV coding requires vestibular input, where possible, it also uses vision to optimize heading estimation during navigation.</p>

Indicate the full web address (DOI or URL) giving public access to these data (if you have any problems with the deposit of your data, please contact contact@neuro.peercommunityin.org). In case all raw data are included in the preprint, indicate the DOI or URL of the preprint. *

You should fill this box only if you chose 'All or part of the results presented in this preprint are based on data'. URL must start with http:// or https://

Indicate the full web address (DOI or URL) giving public access to these scripts (if you have any problems with the deposit of your scripts, please contact contact@neuro.peercommunityin.org). In case all raw scripts are included in the preprint, indicate the DOI or URL of the preprint. *

You should fill this box only if you chose 'Scripts were used to obtain or analyze the results'. URL must start with http:// or https://

Indicate the full web address (DOI, SWHID or URL) giving public access to these codes (if you have any problems with the deposit of your codes, please contact contact@neuro.peercommunityin.org). In case all raw codes are included in the preprint, indicate the DOI or URL of the preprint. *

You should fill this box only if you chose 'Codes have been used in this study'. URL must start with http:// or https://

Keywords (optional)

retrosplenial cortex, self-motion, navigation, vestibular, optic-flow, Neuropixels, head motion, head velocity, head direction

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Behavioral/Cognitive Neuroscience, Electrophysiology, Neuronal assembly, Rodent model system, Systems/Circuit Neuroscience

Suggested reviewers - Suggest up to 10 reviewers (provide names and Email addresses). (Optional)

e.g. John Doe john@doe.com

No need for them to be recommenders of PCI Neuro. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct

Opposed reviewers - Suggest up to 5 people not to invite as reviewers. (Optional)

e.g. John Doe john@doe.com

Submission date

2024-08-29 15:59:23

Recommender

Balázs Hangya

Reviewers

or Register
Submit a preprint

MANAGING BOARD

MEMBER OF

INDEXED BY